~620 km
Expected lifespan, based on hand-researched wear data for this model.

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Durability is generally rated above average due to the added outsole rubber compared to the Epic React, which addresses previous wear issues. However, some skepticism remains about the long-term resilience of the flexible upper, though 100+ mile reports are positive.
The Nike Odyssey React Flyknit 2 is widely regarded as an excellent daily trainer due to its combination of lightweight construction (under 10 oz), responsive React foam cushioning, and a supportive yet comfortable fit. Experts and users consistently praise its versatility for everyday runs and base building, with the cushioning providing enough protection for moderate to long distances. For long runs, the shoe performs well, with reviewers noting comfort and support even on 15+ mile efforts, though some find the forefoot a bit thin for very high mileage or marathon training. The shoe is responsive enough for tempo runs and moderate speedwork, but its weight and cushioning are not optimized for peak race performance, making it less ideal for competitive racing compared to lighter, more aggressive models. The Odyssey React Flyknit 2 is not designed for trail running, lacking the necessary traction and protection for off-road or technical terrain. For recovery runs, the plush yet responsive cushioning and stable ride make it a strong choice, though some may prefer even softer, more forgiving shoes for maximum recovery comfort.
Ideal for Best suited for intermediate to experienced runners who appreciate a lightweight, mildly stable trainer for daily mileage, long runs, and uptempo workouts. Ideal for those who want a responsive ride with enough support for mild overpronation, but who don’t require maximal stability or plushness.
The Odyssey React Flyknit 2 is a lightweight, mild stability trainer suitable for both neutral and stability-seeking runners. The Flyknit upper increases breathability and comfort but may feel less structured in the midfoot compared to traditional uppers. The thin tongue can cause lace pressure if not adjusted carefully. The heel fit is notably secure and padded, while the toebox provides adequate but not generous space. No carbon plate or aggressive stability elements are present; stability comes from the midsole geometry and heel clip.
Sizing: Generally true to size for most runners; some users with narrow feet may find the midfoot less secure unless using heel-lock lacing. Compared to the original Odyssey React, the Flyknit 2 has a slightly less structured midfoot but similar overall fit. No consistent advice to size up or down.
Daily Trainer shoes in NORMA's database last between 320 and 800 km across 694 models. At 620 km, the Nike Odyssey React Flyknit 2 sits in the upper half of that range.
The Nike Odyssey React Flyknit 2 stands out as a lightweight daily trainer that balances soft, responsive cushioning with subtle stability features. Its adaptive Flyknit upper and enhanced outsole grip make it a versatile choice for runners who want comfort and performance in one package.
Full specs, fit notes, and reviews on the Nike Odyssey React Flyknit 2 wiki page.
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The Nike Odyssey React Flyknit 2 lasts about 620 km, based on hand-researched wear data for this model. Your own mileage shifts with body weight, running surface, and how you use the shoe.
Start checking for wear around 372 km (60% of its lifespan). By 496 km the foam and outsole are usually noticeably degraded, and most runners retire the shoe between there and 620 km.
Daily Trainer shoes in NORMA's database range from 320 to 800 km across 694 models. At 620 km, the Nike Odyssey React Flyknit 2 sits in the upper half of that range.
Often, yes. A pair with under 60% wear (roughly 372 km) still has real training life left. NORMA lists second-rotation running shoes with transparent, verified mileage so you know exactly how much life you're buying.